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Engineering & Informatics

Dr Eimear Dolan

BE, PhD

 
researcher
 

Biography

Dr. Eimear Dolan was awarded her PhD in Biomedical Engineering from NUI Galway in 2015 for research in the field of orthopaedics under the supervision of Prof. Laoise McNamara. Prior to this, she graduated with a First Class Honours Degree in Biomedical Engineering from NUI Galway. Since graduating, she has worked as a postdoctoral researcher in Trinity College Dublin (TCD), Royal College of Surgeons (RCSI) and NUI Galway on European Union (EU) funded translational research programs, and Massachusetts Institute of Technology (MIT).  As a postdoctoral researcher Dr Dolan has focused on the development and coupling of medical device systems with smart biomaterials and stem cells for the treatment of myocardial infarction and diabetes. 
Dr. Dolan joined the Discipline of Biomedical Engineering at NUI Galway in September 2018. Her key research interest is in medical devices, their effect on the host cells and coupling therapies to minimally invasive delivery devices. As an independent investigator, her vision is to leverage medical device research to enable both applications in biomaterial and cell/drug delivery and tissue engineering for various disease states. 

Peer Reviewed Journals

  Year Publication
(2020) 'Pre-culture of Mesenchymal Stem Cells within RGD-modified Hyaluronic Acid Hydrogel Improves their Resilience to Ischaemic Conditions'
Gallagher LB;Dolan EB;O'Sullivan J;Levey R;Cavanagh BL;Kovarova L;Pravda M;Velebny V;Farrell T;O'Brien FJ;Duffy GP; (2020) 'Pre-culture of Mesenchymal Stem Cells within RGD-modified Hyaluronic Acid Hydrogel Improves their Resilience to Ischaemic Conditions'. Acta Biomaterialia, [DOI] [ARAN Link] [Details]
(2020) 'Enhancing Delivery of Small-Molecule- and Cell-Based Therapies for Ovarian Cancer Using Advanced Delivery Strategies'
O'Dwyer, J;O'Cearbhaill, RE;Wylie, R;O'Mahony, S;O'Dwyer, M;Duffy, GP;Dolan, EB (2020) 'Enhancing Delivery of Small-Molecule- and Cell-Based Therapies for Ovarian Cancer Using Advanced Delivery Strategies'. Advanced Therapeutics, [DOI] [Details]
(2020) 'Implantable Therapeutic Reservoir Systems for Diverse Clinical Applications in Large Animal Models'
Duffy GP;Robinson ST;O'Connor R;Wylie R;Mauerhofer C;Bellavia G;Straino S;Cianfarani F;Mendez K;Beatty R;Levey R;O'Sullivan J;McDonough L;Kelly H;Roche ET;Dolan EB; (2020) 'Implantable Therapeutic Reservoir Systems for Diverse Clinical Applications in Large Animal Models'. Advanced Healthcare Materials, 9 (11) [DOI] [Details]
(2019) 'Insulin-like growth factor-1 (IGF-1) poly (lactic-co-glycolic acid) (PLGA) microparticles - development, characterisation, and in vitro assessment of bioactivity for cardiac applications'
Hameed, A;Gallagher, LB;Dolan, E;O'Sullivan, J;Ruiz-Hernandez, E;Duffy, GP;Kelly, H (2019) 'Insulin-like growth factor-1 (IGF-1) poly (lactic-co-glycolic acid) (PLGA) microparticles - development, characterisation, and in vitro assessment of bioactivity for cardiac applications'. Journal Of Microencapsulation, [DOI] [Details]
(2019) 'Development of a nanomedicine-loaded hydrogel for sustained delivery of an angiogenic growth factor to the ischaemic myocardium'
O'Dwyer, J,Murphy, R,Dolan, EB,Kovarova, L,Pravda, M,Velebny, V,Heise, A,Duffy, GP,Cryan, SA (2019) 'Development of a nanomedicine-loaded hydrogel for sustained delivery of an angiogenic growth factor to the ischaemic myocardium'. Drug Delivery And Translational Research, [DOI] [Details]
(2019) 'A bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarction'
Dolan, EB;Hofmann, B;de Vaal, MH;Bellavia, G;Straino, S;Kovarova, L;Pravda, M;Velebny, V;Daro, D;Braun, N;Monahan, DS;Levey, RE;O'Neill, H;Hinderer, S;Greensmith, R;Monaghan, MG;Schenke-Layland, K;Dockery, P;Murphy, BP;Kelly, HM;Wildhirt, S;Duffy, GP (2019) 'A bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarction'. Materials Science & Engineering C-Materials For Biological Applications, 103 [DOI] [Details]
(2019) 'An actuatable soft reservoir modulates host foreign body response'
E. B. Dolan, C. E. Varela, K. Mendez, W. Whyte, R. E. Levey, S. T. Robinson, E. Maye, J. O’Dwyer, R. Beatty, A. Rothman, Y. Fan, J. Hochstein, S. E. Rothenbucher, R. Wylie, J. R. Starr, M. Monaghan, P. Dockery, G. P. Duffy, E. T. Roche (2019) 'An actuatable soft reservoir modulates host foreign body response'. Science Robotics, [DOI] [ARAN Link] [Details]
(2019) 'Insulin-like growth factor-1 (IGF-1) poly (lactic-co-glycolic acid) (PLGA) microparticles - development, characterisation, and in vitro assessment of bioactivity for cardiac applications'
Hameed, A,Gallagher, LB,Dolan, E,O'Sullivan, J,Ruiz-Hernandez, E,Duffy, GP,Kelly, H (2019) 'Insulin-like growth factor-1 (IGF-1) poly (lactic-co-glycolic acid) (PLGA) microparticles - development, characterisation, and in vitro assessment of bioactivity for cardiac applications'. Journal Of Microencapsulation, [DOI] [Details]
(2018) 'An injectable alginate/extra cellular matrix (ECM) hydrogel towards acellular treatment of heart failure'
Clive J. Curley, Eimear B. Dolan, Matthias Otten, Svenja Hinderer, Garry P. Duffy, Bruce P. Murphy (2018) 'An injectable alginate/extra cellular matrix (ECM) hydrogel towards acellular treatment of heart failure'. Drug Delivery And Translational Research, [DOI] [Details]
(2018) 'Advanced Material Catheter (AMCath), a minimally invasive endocardial catheter for the delivery of fast-gelling covalently cross-linked hyaluronic acid hydrogels'
Eimear B Dolan, Lenka Kovarova, Hugh O'Neill, Martin Pravda Martin Pravda, Romana Sulakova, Ivana Scigalkova, Vladimir Velebny, Dorothee Daro, Nathalie Braun, Gerard M Cooney, Gabriella Bellavia, Stefania Straino, Brenton L Cavanagh, Aiden Flanagan, Helena M Kelly, Garry P Duffy, Bruce P Murphy (2018) 'Advanced Material Catheter (AMCath), a minimally invasive endocardial catheter for the delivery of fast-gelling covalently cross-linked hyaluronic acid hydrogels'. Journal Of Biomaterials Applications, [DOI] [Details]
(2018) 'Hydrogels in adipose tissue engineering—Potential application in post‐mastectomy breast regeneration'
Niamh A O'Halloran, Eimear B Dolan, Michael J Kerin, Aoife J Lowery, Garry P Duffy (2018) 'Hydrogels in adipose tissue engineering—Potential application in post‐mastectomy breast regeneration'. Journal Of Tissue Engineering And Regenerative Medicine, [DOI] [Details]
(2018) 'Towards Alternative Approaches for Coupling of a Soft Robotic Sleeve to the Heart'
Horvath, MA;Varela, CE;Dolan, EB;Whyte, W;Monahan, DS;Payne, CJ;Wamala, IA;Vasilyev, NV;Pigula, FA;Mooney, DJ;Walsh, CJ;Duffy, GP;Roche, ET (2018) 'Towards Alternative Approaches for Coupling of a Soft Robotic Sleeve to the Heart'. Annals Of Biomedical Engineering, 46 :1534-1547 [DOI] [Details]
(2017) 'The development and mechanical characterisation of a novel reinforced venous conduit that mimics the mechanical properties of an arterial wall'
Dolan, EB;Gunning, GM;Davis, TA;Cooney, G;Eufrasio, T;Murphy, BP (2017) 'The development and mechanical characterisation of a novel reinforced venous conduit that mimics the mechanical properties of an arterial wall'. Journal Of The Mechanical Behavior Of Biomedical Materials, 71 :23-31 [DOI] [Details]
(2017) 'An in vitro investigation to assess procedure parameters for injecting therapeutic hydrogels into the myocardium'
Curley, CJ;Dolan, EB;Cavanagh, B;O'Sullivan, J;Duffy, GP;Murphy, BP (2017) 'An in vitro investigation to assess procedure parameters for injecting therapeutic hydrogels into the myocardium'. Journal Of Biomedical Materials Research Part B-Applied Biomaterials, 105 :2618-2629 [DOI] [Details]
(2017) 'A methylcellulose and collagen based temperature responsive hydrogel promotes encapsulated stem cell viability and proliferation in vitro'
Payne, C;Dolan, EB;O'Sullivan, J;Cryan, SA;Kelly, HM (2017) 'A methylcellulose and collagen based temperature responsive hydrogel promotes encapsulated stem cell viability and proliferation in vitro'. Drug Delivery And Translational Research, 7 :132-146 [DOI] [Details]
(2016) 'Biomaterial-Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives'
O'Neill, HS;Gallagher, LB;O'Sullivan, J;Whyte, W;Curley, C;Dolan, E;Hameed, A;O'Dwyer, J;Payne, C;O'Reilly, D;Ruiz-Hernandez, E;Roche, ET;O'Brien, FJ;Cryan, SA;Kelly, H;Murphy, B;Duffy, GP (2016) 'Biomaterial-Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives'. Advanced Materials (Deerfield Beach, Fla.), 28 :5648-5661 [DOI] [Details]
(2016) 'Thermally induced osteocyte damage initiates pro-osteoclastogenic gene expression in vivo'
Dolan, EB;Tallon, D;Cheung, WY;Schaffler, MB;Kennedy, OD;McNamara, LM (2016) 'Thermally induced osteocyte damage initiates pro-osteoclastogenic gene expression in vivo'. Journal Of The Royal Society Interface, 13 [DOI] [Details]
(2015) 'Mechanical Stimulation of Bone Marrow In Situ Induces Bone Formation in Trabecular Explants'
Birmingham, E;Kreipke, TC;Dolan, EB;Coughlin, TR;Owens, P;McNamara, LM;Niebur, GL;McHugh, PE (2015) 'Mechanical Stimulation of Bone Marrow In Situ Induces Bone Formation in Trabecular Explants'. Annals Of Biomedical Engineering, 43 :1036-1050 [DOI] [Details]
(2015) 'Thermally Induced Osteocyte Damage Initiates a Remodelling Signaling Cascade'
Dolan, EB;Haugh, MG;Voisin, MC;Tallon, D;McNamara, LM (2015) 'Thermally Induced Osteocyte Damage Initiates a Remodelling Signaling Cascade'. Plos One, 10 [DOI] [Details]
(2014) 'How Bone Tissue and Cells Experience Elevated Temperatures During Orthopaedic Cutting: An Experimental and Computational Investigation'
Dolan, EB;Vaughan, TJ;Niebur, GL;Casey, C;Tallon, D;McNamara, LM (2014) 'How Bone Tissue and Cells Experience Elevated Temperatures During Orthopaedic Cutting: An Experimental and Computational Investigation'. Journal Of Biomechanical Engineering-Transactions Of The Asme, 136 [DOI] [Details]
(2012) 'Heat-shock-induced cellular responses to temperature elevations occurring during orthopaedic cutting'
Dolan, EB;Haugh, MG;Tallon, D;Casey, C;McNamara, LM (2012) 'Heat-shock-induced cellular responses to temperature elevations occurring during orthopaedic cutting'. Journal Of The Royal Society Interface, 9 :3503-3513 [DOI] [Details]

Book Chapters

  Year Publication
(2020) 'Cardiac Responses to Biomaterials'
Joanne O’Dwyer, Robert Wylie, Sally Ann Cryan, Garry P Duffy, Eimear B. Dolan (2020) 'Cardiac Responses to Biomaterials' In: Handbook of Biomaterials Biocompatibility. United Kingdom: Woodhead Publishing Series in Biomaterials. [DOI] [Details]
(2018) 'Chapter 1: Techniques for studying mechanobiology'
Eimear B.Dolan, Stefaan W.Verbruggen, Rebecca A.Rolfe (2018) 'Chapter 1: Techniques for studying mechanobiology' In: Mechanobiology in Health and Disease. Oxford, United Kingdom: Academic Press. [DOI] [Details]

External Collaborators

  Name Organisation / Institute Country Description of Collaboration
Prof Ellen Roche Massachusetts Institute Of Technology U.S.A.
Prof Garry Duffy Anatomy, School of Medicine, NUI Galway IRELAND